mediastinitis
Advices
| Priority | Medication | Remarks | 
|---|---|---|
| 
                                              Medication: amoxicilline + clavulaanzuur iv 1000/200mg 6dd 4 weeks + 
                                                                            fluconazol po loading dose 800mg, 400mg 1dd 4 weeks  | 
                    
                                               
                          Remarks: 
                           
                                          community-acquired. voeg alleen fluconazol toe onder bepaalde voorwaarden: zie onder.  | 
                  |
| 
                                              Medication: piperacilline/tazobactam iv 4000/500mg 3dd 4 weeks + 
                                                                            fluconazol po loading dose 800mg, 400mg 1dd 4 weeks  | 
                    
                                               
                          Remarks: 
                           
                                          nosocomiaal voeg altijd fluconazol toe.  | 
                  
| Priority | Medication | Remarks | 
|---|---|---|
| 
                                              Medication: amoxicilline + clavulaanzuur iv 1000/200mg 6dd 4 weeks  | 
                    
                                               
                          Remarks: 
                           
                                          community-acquired  | 
                  |
| 
                                              Medication: piperacilline/tazobactam iv 4000/500mg 3dd 4 weeks  | 
                    
                                               
                          Remarks: 
                           
                                          nosocomiaal  | 
                  
| Priority | Medication | Remarks | 
|---|---|---|
| 
                                              Medication: flucloxacilline iv 6g continuous per 24 hours 6 weeks + 
                                                                            ceftazidim iv 2000mg 3dd 6 weeks  | 
                    
                                               
                          Remarks: 
                           
                                          Geen klep- of vaatprothese in situ  | 
                  |
| 
                                              Medication: vancomycine iv continuous per 24 hours 6 weeks + 
                                                                            ceftazidim iv 2000mg 3dd 6 weeks  | 
                    
                                               
                          Remarks: 
                           
                                          Wel klep- of vaatprothese in situ  | 
                  
Sources
- 
          
            
            
                          
Baddour LM et al. Circulation 2015;132:1435-86.
 
Antimicrobial resources
The following antimicrobial agents have been used in these recommendations:
External antimicrobial resources
Menu position
Metadata
            Swab vid: G-396147.4
            Updated: 09/19/2024 - 23:05
            Status: Published
          
          
General comments
Algemeen: laagdrempelig overleg cardiothoracaal centrum.
Fluconazol:
-in community acquired oesophagus perforatie, voeg ALLEEN fluconazol toe in éen van de volgende gevallen: langdurig PPI gebruik of immunosuppressiva, HIV met CD4<200, niet opknappen na 3 dagen adequate antibiotische therapie.
-In nosocomiale oesophagus perforatie, voeg altijd fluconazol toe.
Vancomycine dosering: zie hoofdstuk 'overig' --> 'vancomycine continu dosering'